Blueberry Compound Could Help Treat Inflammatory Bowel Disease | Medicine

Pterostilbene, a resveratrol-related polyphenolic compound found in blueberries, has strong immunosuppressive properties, according to a study published in The FASEB Journal.

Yashiro et al. evaluated the effect of pterostilbene, a polyphenol found in blueberries, on immune regulation. Image credit: Free-Photos.

Polyphenols are natural products that are consumed by humans as vegetables, fruits, and herbs.

Plant polyphenols possess antioxidant, anti-inflammatory, and anti-carcinogenic properties.

“Resveratrol, a polyphenol found in grapes, is known to have pronounced immunomodulatory and anti-inflammatory effects on animal models of colitis ulcer,” said Dr. Takuya Yashiro, a researcher in the Department of Biological Science and Technology at Tokyo University of Science.

“We investigated the possibility of other compounds structurally similar to resveratrol as a new type of treatment for inflammatory bowel disease.”

In patients with inflammatory bowel disease, the gastrointestinal tract lining contains long-lasting ulcers caused by chronic inflammation due to an elevated immune response in the body. This involves the excessive production of immune system-related molecules called cytokines.

Moreover, two types of immune cells — dendritic cells and T cells — are also involved: at the onset of an immune response, dendritic cells produce inflammatory cytokines and activate T cells to initiate a defense response.

These processes together form a complex pathway that result in a hyperimmune response.

In the study, Dr. Yashiro and colleagues examined the effects of several plant-derived compounds on dendritic cell-mediated T cell proliferation.

Pterostilbene showed stronger immunosuppressive activity than the other candidate compounds.

The researchers found that pterostilbene treatment prevents T cells from differentiating into Th1 and Th17 (subtypes of T cells that elevate the immune response), while increasing their differentiation into regulatory T cells (another subtype known to inhibit inflammation).

They also revealed that pterostilbene inhibits inflammatory cytokine production from dendritic cells by attenuating the DNA-binding activity of a crucial transcription factor PU.1.

When they further tested pterostilbene in mice with inflammatory bowel disease, they found that oral intake of the compound improved symptoms of the disease.

“For disease prevention, it is important to identify the beneficial components in foods and to understand the underlying mechanism by which immune responses and homeostasis are modulated in body,” Dr. Yashiro said.

“Our findings showed that pterostilbene possesses a strong immunosuppressive property, paving the way for a new, natural treatment for inflammatory bowel disease.”

_____

Takuya Yashiro et al. Pterostilbene reduces colonic inflammation by suppressing dendritic cell activation and promoting regulatory T cell development. The FASEB Journal, published online September 22, 2020; doi: 10.1096/fj.202001502R

Recent Articles

Meizu Watch to open a new chapter in the smartwatch industry – see you in Q4 2020

A few months ago, Meizu officially announced that it will release the “Flyme for Watch” system in Q4 2020. The Flyme OS is Meizu’s...

Hot Exoplanet Smaller than Earth Found Orbiting Nearby Red Dwarf | Astronomy

An international team of astronomers has discovered a hot terrestrial planet orbiting the rapidly-rotating low-mass star TOI-540. An artist’s impression of the hot rocky exoplanet...

Universal Pushes Jurassic World: Dominion To June 2022

Jurassic World: Dominion has been delayed by Universal due to the ongoing Coronavirus pandemic. After Regal and Cinemark made the decision to close their doors...

India approves Apple partners and Samsung for $143 billion smartphone manufacturing plan – TechCrunch

Samsung and three major contract manufacturing partners of Apple are among 16 firms to win $6.65 billion incentives under India’s federal plan to...

Related Stories

Leave A Reply

Please enter your comment!
Please enter your name here

Stay on op - Ge the daily news in your inbox